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In-vivo Biology Services
In-vivo Pharmacology
Elevate your research to new heights and uncover groundbreaking discoveries in the realm of In-Vivo Biology which is
the nexus of cutting-edge scientific exploration, renowned for its exceptional features that drive innovation and
discovery. With a seasoned team of expert researchers and scientists at its core, the department offers unmatched
expertise in the field of in-vivo biology. These experts collaborate seamlessly with researchers across various
disciplines, providing tailored solutions to meet unique research objectives. A diverse array of in-vivo models,
from mice to rabbits, coupled with myriad of downstream biomarker estimations enables comprehensive investigations
into an extensive range of biological phenomena. The department boasts a state-of-the-art infrastructure, including
advanced technologies and tools, ensuring researchers have access to the latest innovations. Ethical standards are
paramount, with a deep commitment to the humane treatment and welfare of research animals. This dedication, combined
with efficient workflows and data analysis capabilities, ensures timely and impactful results.
Inflammation Animal Models
Fibrosis Models
Lung fibrosis in mice (LPS/Bleomycin)
Liver fibrosis in mice (CCl4)
Kidney Models
Unilateral Ureteral Obstruction (UUO) in mice
Adenine diet induced Kidney Injury in mice
5/6 Nephrectomized Animal Model
Wound Healing
Diabetic Wound Healing in mice
Inflammatory Bowel Disease Models
DSS & Oxazolone-induced Ulcerative Colitis in mice
TNBS-induced Colitis in rats (acute)
Systemic Lupus Erythematosus (SLE) Model
MRL/lpr
Arthritis Model
Collagen induced arthritis (CIA)
Collagen Antibody Induced Arthritis (CAIA)
Skin Models
TPA induced contact dermatitis
Oxazolone induced allergic contact dermatitis
Imiquimod induced psoriasis in mice and rats
IL23 induced acanthosis in mice and rats
Neuropathic Pain Models
CCI/SNI/PSNL models (rats & mice)
SNL model (rats)
Formalin induced nociception
Capsaicin induced nociception
Disease Specific Pain Models
Chemotherapy induced mechanical allodynia
Bone cancer pain model
Streptozotocin induced diabetic neuropathy
Inflammatory Pain Models
CFA induced mechanical hyperalgesia
Alzheimer’s Disease / neurodegeneration Models
MOG-EAE model of multiple sclerosis in rats and mice
Dexamethasone induced muscle atrophy in mice
Intrathecal / stereotaxic surgeries to inject compounds in different parts of spinal
cord and
brain
Isolation of various brain regions using brain matrices
Collection of CSF in rats
Experience in target validation and development of target engagement models
PK-PD Correlations using free tissue and brain concentrations
Glucose tolerance test in rat and mice
Oral
Intraperitoneal
Intravenous
Pyruvate tolerance test
Insulin tolerance Test
Genetic disease models of diabetes
ZDF rats
ob/ob mice
db/db mice
DIO models
Rat
Mice
nSTZ-HFD fed NASH mice model
CDA-HFD NASH model
NAFLD mouse model
STZ induced diabetic model in mice and rats
STZ induced diabetic nephropathy in mice and rats
GI emptying model in mice
Xenograft Solid Tumor Models
Pancreatic cancer (MiaPaCa2, PANC1 & BxPC3)
Lung cancer (A549)
Gastric cancer (SNU-5 & Hs746T)
Colon cancer (HCT116 , Colo 205, SW620, DLD-1 & LoVo)
Prostate cancer (PC3, 22RV1 & DU145)
Ovarian cancer (OVCAR3)
Breast cancer (MCF7)
Melanoma cancer (A375)
Xenograft Liquid Tumor Models
Acute Myeloid Leukemia (KG-1)
Chronic Myeloid Leukemia (K-562)
Erythroleukemia (HEL 92.1.7)
Orthotopic Xenograft Models
Glioblastoma (U87-MG)
Subcutaneous Syngeneic Models
Colon Cancer (CT26)
Melanoma Cancer (B16F10)
Breast Cancer (4T1, EMT6)
Kidney Cancer (Renca)
Lung Cancer (KLN205 & LL/2 (LLC1))
Pancreatic Cancer (LTPA)
Orthotopic Syngenic Tumor Model
Breast Cancer (4T1, EMT6)
Kidney Cancer (Renca)
Luciferase cell lines
A total of 27 cell lines are available with Luc tagging for IVIS based xenograft
models
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