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Custom Protein Production Services-Jubilant Biosys

Jubilant Biosys offers a portfolio of structural biology services, including custom protein production, SPR assays, crystallization, and X-ray structure determination to facilitate your drug discovery and research needs. Our custom protein production team has PhD and MS level scientists trained from premier institutions and Pharma across the world. With this immense experience, the team provides consulting and guidance through every step of the process with strategic flexibility.

We are committed to providing high-quality protein expression and purification services to produce recombinant proteins for our global customers through a flexible production scale model. We work in partnership with our clients to meet their customized expression and purification needs and ensure protein production.

Proteins are important biological macromolecules as they play key roles in almost every biological process of a living organism. Determining and understanding the 3D structure of a protein is essential for deciphering the mechanistic details about how a protein performs its activities.

In small molecule drug discovery of any therapeutic area, it is a prerequisite to produce a functionally active recombinant protein that is equivalent to the native enzyme to understand its function/activity in an in-vitro setting.

Towards this, the Structural Biology team at Jubilant Biosys provides:

Functionally active recombinant soluble proteins, overexpressed from E. coli or baculovirus-insect cells or mammalian cells for biophysical/biochemical assays and crystallography

Stable cell lines that express protein-of-interest.

JubiIant Biosys offers high-quality proteins for enzymatic assays, high throughput screening, biophysical and structural studies. The team has worked on -80 protein targets and delivered more than 300 proteins. Recombinant protein services helped customers' need for high throughput screening activity.

  • Expression Constructs design
  • Screening in various expression systems (E.coli, baculovirus-insect and mammalian cells)
  • Expression optimization and scale-up
  • Co-expression with chaperones or regulatory domains
  • Refolding from bacterial inclusion bodies
  • Various chromatography techniques with highly efficient FPLC purification systems (e.g AKTA, NGC)
    • Affinity chromatography
    • Ion exchange chromatography
    • Size exclusion chromatography
  • Large scale cell culture (insect/mammalian) in flasks
  • Purity >95% (on SDS-PAGE)

JubiIant Biosys also has the experience in generating stable cells in different cell backgrounds by using plasmid-based transfection. We have successfully delivered stable cells expressing target genes that encompass kinases, carboxylases, ion-channels, GPCRs, lipases, etc. in adherent and suspension formats.


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