Target Approaches
Immune & inflammation regulatorsTranscription factors
Immune modulators are pivotal in the management of a wide array of conditions, including Cancer, allergies, rheumatoid arthritis (RA), inflammatory conditions such as psoriasis and atopic dermatitis, inflammatory bowel disease (IBD), asthma, and SLE.
The advent of small-molecule immune modulators has introduced a new dimension to immunotherapy. These molecules offer several distinct benefits, including oral bioavailability, the potential for crossing the blood-brain barrier, and the ability to affect intracellular signaling pathways.
At Jubilant Biosys, our services extend to the development of immune modulator assays, encompassing both high-throughput screening and structure-activity relationship (SAR) support. Our bespoke screening platforms are designed to facilitate the discovery and optimization of small-molecule immune modulators, ensuring a comprehensive approach to drug development.
- Bioluminescent Reporter assay (Luminescence).
- Immuno-phenotype analysis (Flowcytometry, Immune cell activity).
- Cytokine profiling (Multiplex MSD, Luminex, ELISA, HTRF).
- Protein expression analysis (Jess, In-cell western, Traditional Western blotting, ELISA, AlphaLISA).
- Gene expression analysis (Realtime PCR).
- Primary cell and Blood based assays.
- Custom made phenotypic assays based on target biology.
Jubilan Biosys can support client projects involving Immune & inflammation -small molecule regulator drug discovery at all stages of preclinical development ranging from protein production to preclinical candidate nomination. Medicinal chemistry strategies are driven by structure-based drug design using information provided by our in-house X-ray crystallographers.