GPCRs & Ion Channels

G protein-coupled receptors (GPCRs) and Ion Channels are involved in virtually all physiological processes and implicated in all major disease areas, making them the most extensive family of targets for existing approved drugs.

GPCRs & Ion Channels

Target Approaches

GPCRs & Ion Channels

G protein-coupled receptors (GPCRs) and Ion Channels are involved in virtually all physiological processes and implicated in all major disease areas, making them the most extensive family of targets for existing approved drugs. The field of GPCRs & Ion channel drug discovery has seen significant advancements, including the development of biased signaling and allosteric modulators, which are now key components in the creation of GPCR & Ion Channel assays.

Jubilant Biosys services include the development of GPCR & Ion Channel assays, high-throughput screening, and structure-activity relationship (SAR) support. Custom-tailored screening platform that include below list of assays.

  • Agonist-induced IP1/IP3 accumulation (HTRF/ELISA).
  • Agonist-induced cAMP/cGMP generation (HTRF).
  • Agonist-induced Calcium flux assay (FLIPR Penta).
  • Agonist-induced Potassium flux assay (FLIPR Penta).
  • Voltage-sensitive dye assays (FLIPR Penta).
  • Agonist-induced ß-arrestin translocation (Enzyme complementation based Chemiluminescence).
  • Custom made phenotypic assays based on target biology.

Jubilant Biosys medicinal and computational chemists have extensive experience in GPCR drug design. We can support client projects at all stages of preclinical development, from target identification, protein production, assay development & screening to crystallography and in-vivo testing up till preclinical candidate nomination.