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Medicinal Chemistry
Medicinal chemistry is the art of designing and synthesizing compounds which are to be optimized and ultimately become novel drugs to treat diseases. It is a multidisciplinary field rooted in various basic disciplines such as organic chemistry, computational chemistry, biology, pharmacy, pharmacology and toxicology.
Jubilant Biosys offers best-in-class drug discovery chemistry services, supported by our highly talented scientists and state-of-the-art infrastructure. Collectively, our medicinal chemists have rich experience in structure-based drug design in various therapeutic areas contributing largely to our integrated drug discovery programs and standalone medicinal chemistry services.
Medicinal Chemistry Services
The Jubilant Biosys offers the following MedChem services:
- Design and synthesis of novel chemical entities for hit finding strategies, hit-to-lead identification and lead optimization
- Designing novel chemical entities (in collaboration with in Silico Molecular Modelling Group)
- Biological profiling of the designed compounds (In collaboration with our in-vitro and in-vivo biology & DMPK groups)
- Structure based drug design (in collaboration with Collaboration with structural biology group.)
- IPR evaluation and generation of the scaffolds
The Jubilant Biosys team responsible for implementing medicinal chemistry services comprises knowledgeable and seasoned medicinal chemists who are not only well-trained in one discipline but have experience in bringing all the elements together into one focused drug discovery program.
Working together with our Structural Biology and Computational Chemistry groups, the MedChem team is well versed in interpreting biological data to optimize compounds to meet all the requirements of a viable clinical candidate.
This pharmaceutical chemistry team:
- Has a track record of delivering clinical candidates starting from, for example, in-silico screening hits, in a short time
- Has expertise in every step of the drug discovery process, starting from early-stage target identification, through hit identification, hit to lead identification and then lead optimization, leading to the identification of pre-clinical candidates
- Comprises of ~150 research chemists
The medicinal chemistry team has a performance history of troubleshooting solving the various problems often encountered during the optimization discovery and optimization process, such as potency, selectivity, specificity, off-target activity, physicochemical properties, DMPK related issues, safety-related issues and such. They have accumulated expertise in various therapeutic areas over the years, including, but not limited to, oncology, metabolic disorders, inflammation and CNS.
Chemists at our Contract Research, Development and Manufacturing Organization have worked on more than 85 integrated drug discovery programs yielding many pre-clinical candidates, out of which numerous compounds have advanced into the later phase of developments & clinic. The group also has strong organic synthesis capabilities and can offer pharmaceutical chemistry services independently or as part of an integrated program.
