Target Approaches
Non-Kinase Enzymes
Jubilant Biosys offers comprehensive services in the development of non-kinase enzymatic assays, including high-throughput screening, and structure-activity relationship (SAR) support. We have wide range of experience in developing drugs for enzymes of various classes such as Metalloproteases, Methyl transferases, histone deacetylases, proteases. Our custom-tailored screening platforms encompass a wide array of biochemical and cell based assays, designed to meet the specific needs of our clients in their pursuit of novel enzyme therapeutics.
- Substrate conversion (Absorbance, Fluorescence, LC-MS-MS & RapidFire).
- Peptide cleavage (Absorbance, Internally Quenched Fluorescence).
- Scintillation Proximity assay (Radioligand assay).
- Long term cell proliferation assays (CTG, RTG).
- Custom made phenotypic assays based on target biology.
Jubilan Biosys can support client projects at all stages of preclinical development ranging from protein production to preclinical candidate nomination. Medicinal chemistry strategies are driven by structure-based drug design using information provided by our in-house X-ray crystallographers.