• Single Dose Toxicity Studies in Mice and Rats.
• Dose Range Finding Studies in Rats.
• Repeated Dose Toxicity Studies (one month, 3 months and 6 months in rats).
• Histopathological Studies
• Toxicokinetics Studies

Genotoxicity

• Micronucleus test in mouse or rat bone marrow
• Mammalian bone marrow chromosome aberration test in rats